Calling on the cancer sleuths: how cell biologists will do the detective legwork of the postcancer genome era
نویسنده
چکیده
Novel mRNA-containing cytoplasmic granules in ALK-transformed cells M. Fawal, O. Jean-Jean, N. Vanzo, and D. Morello 726–735 The NPM-ALK oncogenic tyrosine kinase is able to assemble large cytoplasmic structures that concentrate messenger RNAs (mRNAs) but do not include components of mRNA translation or degradation machineries. ALK-containing granules (AGs) move on microtubules. Through their ability to scan the cytoplasm and capture mRNAs, AGs may be potent actors of cell transformation.
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